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Cancer Germline Essay

Cancer Germline Essay

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The CG genes or cancer-germline elements are a group of germline-specific factors that depend on DNA methylation for repression in physical tissues. In a variety of tumors, the promoter is demethylated, which activates their transcription. The underlying tumor-specific mechanism is not clear. Scientists recently suggested that the CG gene expression could be a hallmark of stem cells (Sulik, 2010).

The expression of the genes in tumors shows the expansion of aggressive cancer stem cells. There is the analysis of the of several CGs in humans in embryonic and adult stages. In the beginning, there are no symptoms. The signs appear as their mass grows or ulcerates. The findings of the study depend on the type and their location. Some are specific. However, they could also appear if the person has other conditions.

It is common that cancer patients have previously suffered from other diseases. Therefore, they could have assumed the signs and symptoms. It could be a local spread from the original site, lymphatic transfer to regional lymph nodes, or via the blood to other locations. Scientists call it metastasis. If it travels through a hematogenous route, it will move to the whole body.

However, cancer can grow at a selected site only. The symptoms of the metastatic condition depend on the tumor's location, for example, enlarged lymph nodes, liver, or spleen. The patient can feel them in the abdomen, fracture, and neurological signs (Malkin, 2011).

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